| 主な論文・著書 |
＜著書＞
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Recent Advancement in Prodrugs (共著、チャプター11を担当、2020)
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＜学術論文＞
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Effects of Steric Hindrance and Electron Density of Ester Prodrugs on Controlling the Metabolic Activation by Human Carboxylesterase. Takahashi, M.; Hirota, I.; Nakano, T.; Kotani, T.; Takani, D.; Shiratori, K.; Choi, Y.; Haba, M.; Hosokawa, M. Drug Metab. Pharmacokinet. 2021, 100391.
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Design, Synthesis and Biological Evaluation of Water-Soluble Phenytoin Prodrugs Considering the Substrate Recognition Ability of Human Carboxylesterase 1. Takahashi, M.; Lee, Y. J.; Kanayama, T.; Kondo, Y.; Nishio, K.; Mukai, K.; Haba, M.; Hosokawa, M. Eur. J. Pharm. Sci. 2020, 152, 105455.
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Structure-Activity Relationship of Atorvastatin Derivatives for Metabolic Activation by Hydrolases. Mizoi, K.; Takahashi, M.; Sakai, S.; Ogihara, T.; Haba, M.; Hosokawa, M. Xenobiotica 2020, 50 (3), 261–269.
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Investigation of the Chiral Recognition Ability of Human Carboxylesterase 1 Using Indomethacin Esters. Takahashi, M.; Takani, D.; Haba, M.; Hosokawa, M. Chirality 2020, 32 (1), 73–80.
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Synthesis and Evaluation of Haloperidol Ester Prodrugs Metabolically Activated by Human Carboxylesterase. Takahashi, M.; Uehara, T.; Nonaka, M.; Minagawa, Y.; Yamazaki, R.; Haba, M.; Hosokawa, M. Eur. J. Pharm. Sci. 2019, 132, 125–131.
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Chemical Synthesis of an Indomethacin Ester Prodrug and Its Metabolic Activation by Human Carboxylesterase 1. Takahashi, M.; Ogawa, T.; Kashiwagi, H.; Fukushima, F.; Yoshitsugu, M.; Haba, M.; Hosokawa, M. Bioorganic Med. Chem. Lett. 2018, 28 (6), 997–1000.
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Synthesis and Evaluation of Atorvastatin Esters as Prodrugs Metabolically Activated by Human Carboxylesterases. Mizoi, K.; Takahashi, M.; Haba, M.; Hosokawa, M. Bioorg. Med. Chem. Lett. 2016, 26 (3), 921–923.
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Unprecedented 8,9′-Neolignans: Enantioselective Synthesis of Possible Stereoisomers for Structural Determination. Takahashi, M.; Suzuki, N.; Ishikawa, T.; Huang, H.-Y.; Chang, H.-S.; Chen, I.-S. J. Nat. Prod. 2014, 77 (12). 2585-2589.
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Enantioselective Formal Synthesis of (-)-Podophyllotoxin from (2 S,3 R)-3-Arylaziridine-2-Carboxylate. Takahashi, M.; Suzuki, N.; Ishikawa, T. J. Org. Chem. 2013, 78 (7). 3250-3261.
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